Brief Communications Impairment of Select Forms of Spatial Memory and Neurotrophin-Dependent Synaptic Plasticity by Deletion of Glial Aquaporin-4

نویسندگان

  • Vanessa A. Skucas
  • Ian B. Mathews
  • Jianmin Yang
  • Qi Cheng
  • Andrew Treister
  • Aine M. Duffy
  • Alan S. Verkman
  • Barbara L. Hempstead
  • Marcelo A. Wood
  • Devin K. Binder
  • Helen E. Scharfman
چکیده

Vanessa A. Skucas,1 Ian B. Mathews,1 Jianmin Yang,2 Qi Cheng,1 Andrew Treister,3 Aine M. Duffy,1 Alan S. Verkman,4 Barbara L. Hempstead,2 Marcelo A. Wood,3 Devin K. Binder,5 and Helen E. Scharfman1,6 1The Nathan Kline Institute for Psychiatric Research, Center for Dementia Research, Orangeburg, New York 10962, 2Department of Medicine, Division of Hematology/Oncology, Weill Medical College of Cornell University, New York, New York 10065, 3Department of Neurobiology and Behavior, University of California at Irvine, Irvine, California 92697, 4Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California at San Francisco, San Francisco, California 94143-0521, 5Center for Glial-Neuronal Interactions, Division of Biomedical Sciences, University of California at Riverside, Riverside, California 92521, and 6Departments of Child & Adolescent Psychiatry, Psychiatry, and Physiology & Neuroscience, New York University Langone Medical Center, New York, New York 10016

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Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4.

Aquaporin-4 (AQP4) is the major water channel in the CNS and is primarily expressed in astrocytes. Little is known about the potential for AQP4 to influence synaptic plasticity, although many studies have shown that it regulates the response of the CNS to injury. Therefore, we evaluated long-term potentiation (LTP) and long-term depression (LTD) in AQP4 knock-out (KO) and wild-type mice. KO mic...

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Aquaporin-4 (AQP4) is the major water channel expressed in the central nervous system (CNS) and is primarily expressed in glial cells. Many studies have shown that AQP4 regulates the response of the CNS to insults or injury, but far less is known about the potential for AQP4 to influence synaptic plasticity or behavior. Recent studies have examined long-term potentiation (LTP), long-term depres...

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تاریخ انتشار 2011